Evaluation of the Analgesic Effects of Cannabinoids in Orange-winged Amazon Parrots (Amazona amazonica)

David Sanchez-Migallon Guzman, LV, MS, Dipl ECZM (Avian, Small Mammal), Dipl ACZM, University of California, Davis School of Veterinary Medicine

Previous published studies from our laboratory have evaluated the pharmacokinetics of cannabinoids in orange- winged Amazon parrots and have shown to be well tolerated and have a favorable pharmacokinetic profile. This was the first study to evaluate the pain-relieving effects of cannabinoids in any parrot species. The objective was to evaluate the analgesic effect and duration of action of two dosages of cannabidiol and cannabidiolic acid rich hemp extract in orange-winged Amazon parrots in a blinded balanced cross-over study using withdrawal thresholds to noxious thermal stimulus. Sedative and agitation behaviors were also monitored and scored during the study. The results support the use of this formulation of hemp-rich cannabinoids for pain management in this species.